WebSep 25, 2012 · CTCF is involved in the regulation of both miR-125b1 and miR-375, indicating that there are various patterns of CTCF-associated epigenetic regulation of miRNAs. CTCF may also play a key role in the pluripotency of cells through the regulation of miR-290 cluster. These observations suggest that CTCF-mediated regulation of … WebApr 5, 2024 · Pluripotency genes were downregulated by Ctcf knockdown (Figure 2A) and upregulated by Ctcf overexpression (Figure 2B), thus exhibiting a clear mirror pattern (Figure 2C). There was a similar but …
CTCF functions as an insulator for somatic genes and a …
WebApr 5, 2024 · Pluripotency genes were downregulated by Ctcf knockdown (Figure 2A) and upregulated by Ctcf overexpression (Figure 2B), thus exhibiting a clear mirror pattern (Figure 2C). There was a similar but inverted relationship for a selective set of somatic genes, as exemplified by Lamb3 , and Krt14 ( Figure 2 C). Web1 day ago · Having identified a reduction in fragile nucleosome occupancy upon Smarca4 depletion at established (promoter, CTCF-bound) and novel (gene-distal DHS) fragile nucleosome-bound genomic locations, we next examined whether this change occurs over other genomic locations, including nucleosome remodeling factor and pluripotency … how can humans decrease pollution
Dynamic enhancer partitioning instructs activation of a growth …
WebApr 5, 2024 · Pluripotency genes were downregulated by Ctcf knockdown (Figure 2 A) and upregulated by Ctcf overexpression (Figure 2 B), thus exhibiting a clear mirror pattern … WebDec 10, 2024 · Here, we uncover a novel and complementary role of Nup93 and CTCF in modulating the organization and function of the HOXA gene locus in the NT2/D1 embryonal human carcinoma cell line, which differentiates into a neuroectodermal lineage upon retinoic acid (RA) treatment. ChIP-seq analysis of Nup93 in differentiated cells revealed an … WebNov 28, 2024 · Interestingly, terminal differentiation of neural progenitor cells does not appear to further promote the frequency of contacts between convergent CTCF sites (Bonev et al., 2024), favoring a model in which the loss of pluripotency marks a critical transition required to fully establish loops and chromatin boundaries. In light of the data ... how can humans combat climate change